Growing Body of Published Research

Peregrine Pharmaceuticals is a clinical-stage biopharmaceutical company developing first-in-class monoclonal antibodies focused on the treatment and diagnosis of cancer.

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Our PS-targeting and TNT technologies are supported by extensive published research. For additional information, please reference:

PS-Targeting Oncology Publications

Yi Yin, Xianming Huang, Kristi D. Lynn, and Philip E. Thorpe, Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation, Cancer Immunology Research: DOI: 10.1158/2326-6066.CIR-13-0073
Brendan F. Judy, Louis A. Aliperti, Jarrod D. Predina, Daniel Levine, Veena Kapoor, Philip E. Thorpe, Steven M. Albelda and Sunil Singhal, Vascular Endothelial–Targeted Therapy Combined with Cytotoxic Chemotherapy Induces Inflammatory Intratumoral Infiltrates and Inhibits Tumor Relapses after Surgery , Neoplasia: 2012, Volume 14, Number 4
David E. Gerber, Alison T. Stopeck, Lucas Wong, Lee S. Rosen, Philip E. Thorpe, Joseph S. Shan, and Nuhad K. Ibrahim, Phase I Safety and Pharmacokinetic Study of Bavituximab, a Chimeric Phosphatidylserine-Targeting Monoclonal Antibody, in Patients with Advanced Solid Tumors , Clinical Cancer Research: 2011, 11-1074
Paul DeRose, Philip E. Thorpe & David E Gerber, . Immunotherapy: 2011, Vol. 3, No. 8, Pages 933-944
Xianming Huang, Dan Yea and Philip E. Thorpe, Enhancing the potency of a whole-cell breast cancer vaccine in mice with an antibody-IL-2 immunocytokine that targets exposed phosphatidylserine . Vaccine: 2011, doi:10.1016/j.vaccine.2011.04.082
Hogg, R.T., Thorpe, P.E., Gerard, R.D., Retargeting adenoviral vectors to improve gene transfer into tumors , Cancer Gene Therapy: 2010, doi: 10.1038/cgt.2010.78
Liang, Y., Besch-Williford, C., Benakanakere, I., Thorpe, P.E., and Salman M. Hyder, Breast Cancer Research and Treatment: 2010, Volume 125, Number 2, 407-420
Thorpe, P.E., . Thrombosis Research 2010, Apr;125 Suppl 2:S134-7
He, J. Thorpe, P.E., et al, Antiphosphatidylserine Antibody Combined with Irradiation Damages Tumor Blood Vessels and Induces Tumor Immunity in a Rat Model of Glioblastoma . Clinical Cancer Research, 2009, 15(22):6871–80
Marconescu A, Thorpe P.E., . Biochemica et Biophysica Acta 2008, 1778(10):2217-24
Jennewein M., Thorpe, P.E., et al, Vascular imaging of solid tumors in rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine . Clinical Cancer Research, 2008, 14(5):1377-85
He, J. Luster, T., Thorpe, P.E., Radiation-Enhanced Vascular Targeting of Human Lung Cancers in Mice with a Monoclonal Antibody That Binds Anionic Phospholipids . Clinical Cancer Research, 2007, 13, 5211
Beck, A.W., Thorpe, P.E., et al, Combination of a monoclonal antiphosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice . International Journal of Cancer, 2005, Volume 118 Issue 10, 2639 - 2643
Huang, X., Thorpe, P.E., et al, A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice . Cancer Research 2005, 65, 4408-4416
Ran, S., Thorpe, P.E., et al, Antitumor Effects of a Monoclonal Antibody that Binds Anionic Phospholipids on the Surface of Tumor Blood Vessels in Mice . Clinical Cancer Research 2005, Vol. 11, 1551-1562
Ran, S., Thorpe, P.E., et al, Increased Exposure of Anionic Phospholipids on the Surface of Tumor Blood Vessels . Cancer Research 2002, 62, 6132-6140

PS-Targeting Imaging Publications

Jason H. Stafford1, Guiyang Hao, Anne M. Best, Xiankai Sun, Philip E. Thorpe. PLoS ONE 8(12): e84864. doi:10.1371/journal.pone.0084864

. Jian Gong, Richard Archer, Michael Brown, Seth Fisher, Connie Chang, Matthew Peacock, Christopher Hughes, Bruce Freimark, Molecular Imaging, Vol 12, No 4 (June 2013): pp 244–256

. Marc Jennewein, Matthew A. Lewis, Dawen Zhao, et al., Clinical Cancer Research 2008;14:1377-1385
. Dawen Zhao, Jason H. Stafford†, Heling Zhou and Philip E. Thorpe, Translational Oncology, Volume 4, Number 6, December 2011, pp. 355–364
. Debabrata Saha, Linda Watkins, Yi Yin, Philip Thorpe, Michael D. Story, Kwang Song, Pavithra Raghavan, Robert Timmerman, Benjamin Chena, John D. Minna, and Timothy D. Solberg, Radiation Research 2010 July ; 174(1): 62–7
. Jason H. Stafford and Philip E. Thorpe, Neoplasia, Volume 13, Number 4 April 2011, pp. 299–308

PS-Targeting Antiviral Publications

Moody, M.A., Haynes, B.F., et al, Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce β-chemokines . The Journal of Experimental Medicine, 2010, vol. 207 no. 4 763-776
Soares MM, King SW, Thorpe PE, Targeting inside-out phosphatidylserine as a therapeutic strategy for viral diseases . Nature Medicine 2008 Dec;14(12):1357-62

Cotara Publications

Sloan, A.E., Hdeib, A. . Expert Opinion on Biological Therapy, 2011, doi:10.1517/14712598.2011.579097
Jensen, R. et al, Clinical Update: Treatment of Glioblastoma Multiforme with Radiolabeled Antibodies that Target Tumor Necrosis , Current Cancer Therapy Reviews, 2010, Volume 6, Number 1, February 2010 , pp. 13-18
Shapiro, W.R., Shan, J.S., et al, 2006. . Expert Opinion on Biological Therapy, 2006, 6 (5):539-45
Patel, S.J., Shan, J.S., et al, Safety and feasibility of convection-enhanced delivery of Cotara for the treatment of malignant glioma : initial experience in 51 patients. Neurosurgery, 2005, Jun;56(6):1243-52; discussion 1252-3.

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